The results of this study are important because not all bone marrow cell
compositions are the same," said the study's principal investigator, Pr.
Dr Helmut Drexler, from the University of Freiburg, who led the research, said, 'Our results lend support to the concept that autologous (patient's own) bone marrow cells
can be used to enhance left-ventricular functional recovery in patients after acute myocardial infarction (heart attack).
Large-scale clinical-end point trials are now needed to assess the effect of intracoronary infusion of bone marrow cells
on morbidity and mortality in patients," said Dr.
The study found strong evidence of a distinct bone marrow cell
that is the source of two different lines of cells, one of which produces red and white blood cells, and the other of which helps build bone, according to Edwin Horwitz, M.
The importance of the present study is that it shows that intracoronary delivery of bone marrow cells
improves function and flow in patients with old myocardial infarction.
Therefore, the ability to produce clinical quantities of these cells from a much smaller starting sample, the basis of Aastrom's proprietary technology, is intended to provide a therapeutic substitute for medical applications that are treatable with large volumes of bone marrow cells
Previous studies have described the A2bAR as anti-inflammatory and protective against kidney ischemia, cardiac reperfusion injury and restenosis, typically via bone marrow cell
Our results confirm that whole cells are not necessarily required in order to see the beneficial effects of bone marrow cell
therapy," Yeghiazarians added.
Petersen's team took bone marrow from male rats and transplanted it into female rats, reasoning that because the Y chromosome is unique to males, it would serve as a genetic tracer for the progress of male-derived marrow cells
throughout the female's body.
In the process, the scientists noted that some of these receptor-activating antibodies have unexpected effects on marrow cells
, causing them to mature into radically different cell types, such as neural cells.
The combination of Ig-GAD2 and bone marrow cells
did result in production of new beta cells, but not in the way we expected," Zaghouani said.
The marrow cells
relieved pain in less than one day, and the effect lasted for over a month, whether the cells were administered at four or 14 days after injury.