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The Maturational Process and the Facilitating Environment. In patients with acute gender problems, the findings may have significant implications for decisions such as the prescription of pubertyblocking medications to decrease the pressure of ego-dystonic maturational somatic changes (Cohen-Kettenis & Pfafflin, 2003) or the initiation of steps toward gender reassignment as described in the Standards of Care for Gender Identity Disorders (Meyer et al. Because of this diversity, the critical period for the effects of CPF exposure depends highly upon the maturational stage of each brain region as well as the specific neurotransmitter, producing a wide window of vulnerability with shifting regional and cellular targets as development proceeds (Pope 1999; Rice and Barone 2000; Slotkin 2004). |
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