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The maximum dose (4 micrograms) passed the CPMP criteria at 21 days and was well tolerated.
The 2 and 4 microgram doses achieved the CPMP defined immune response at 56 days, with the maximum dose passing the criteria at 21 days.
At the maximum dose, JENTADUETO showed placebo-corrected reductions in hemoglobin A(1c) (HbA(1c) or A1C) levels of up to 1.
The prescription-only drug is taken by hundreds of thousands every year - but just two tablets over the maximum dose of eight a day can kill.
Goldstein, a principal investigator in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF), observed that the three trials were all dose-escalation studies, in which the investigators advanced the patients to a maximum dose as tolerated.
But we really haven't done our job until we've pushed them up to the maximum dose.
Key objectives of this portion of the study will be to evaluate the compatibility and safety of administering these two agents together, and to determine the maximum dose of MGCD0103 that can safely be administered in this combination.
5 mg and the maximum dose is 40/25 mg, the company added.
The high efficacy rates are a function of the much higher dose of radiation that can be used, compared with conventional external-beam radiation, which is limited to a maximum dose of 7,000 rad.
As defined in this guidance, Exploratory IND studies are performed at microdose levels not to exceed 1/100th of the dose calculated to yield a pharmacological effect with a maximum dose of 100 ug.
reported today completion of enrollment into a maximum dose tolerance study of investigational product Xerecept (corticorelin acetate) in pediatric patients who were dependent on chronic Decadron (dexamethasone) dosing due to peritumoral brain edema associated with cerebral tumours.
Allergy sufferers with sweaty hands could be subjected to 320 times the recommended maximum dose of the metal in just five minutes.

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