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Duplication of normal genes [right arrow] ultrafast metaboliser.
Colour is thought to show your constitutional leanings: so the brown- eyed, for example, tend to be poor metabolisers of fats; the blue-eyed are liable to develop acid conditions such as arthritis; while those with mixed irises tend to suffer poor digestion.
As well as age-related changes in metabolic processes, there are segments of the population who may unknowingly be genetically poor metabolisers for particular drug metabolism pathways, with the result that drug dosage should be reduced to avoid adverse effects.