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Absorption therefore occurs after these agents are metabolized (hydrolyzed) to bioactive aglycones by intestinal bacteria (Kobashi et al.
The clinical utility would be to appropriately dose medications that could cause harm if not fully metabolized, especially in the elderly or in cases where patients are receiving multiple drugs," he added.
Alternatively, since clozapine is also metabolized by the 1A2 isoenzyme of cytochrome P450, some kind of competitive inhibition may have been involved.
Artificial sweeteners used in diet pops are not metabolized by oral bacteria and, therefore, diet pops do not contribute to the caries experience.
Among the many potential applications of this approach is the treatment of HIV and HCV patients with protease inhibitors, which are primarily metabolized by CYP, the gene silenced by AVI-4557.
xTAG CYP2D6 Kit is an IVD assay that analyzes a patient's CYP2D6 genotype from DNA extracted from a blood sample to aid physicians in determining therapeutic strategy for drugs metabolized by the cytochrome P450 2D6 gene product.
Phthalates are metabolized and excreted quickly; these metabolites, rather than the parent diesters, are believed to be the active toxicants.
Scientists are striving to understand how fat is metabolized and how excess fat leads to diseases such as diabetes.
Both are prodrugs that must be metabolized in order to release their active ingredients, Marilyn R.
The other potential source of problems lies with the fact that caffeine is metabolized by the 1A2 isoenzyme of cytochrome P450.
Kaletra is metabolized in the liver by cytochrome P450, almost wholly by the CYP3A isoform.
Synthetic hormones act as toxins in the body because they are not metabolized the same way human 'bioidentical' hormones are metabolized.