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Before starting our previous intraobserver variability study, we consulted an independent statistician to help determine the sample size necessary to demonstrate noninferiority of WSI versus microscope slide interpretation.
Investigating the surface chemistry of several commercially available microscope slides (which are referred to as "hydrophobic" due to their water-repulsing characteristics) and slides which were "hydrophilic" in nature, we compared the ability of hydrophobic and hydrophilic slides in two functional areas common in IHC: tissue retention and reagent dispersal.
When I found skillfully prepared Victorian-era microscope slides listed under the category "Folk Art" in an antique dealer's online catalog, it led not only to my acquiring them but also to the beginning of a journey involving Internet and library research, trips to herbaria, field collecting excursions, and, finally, to the development of a PowerPoint lecture for community college biology students.
Cells are first suspended in fluid before being filtered and deposited onto a microscope slide by a computerised instrument.
Several previous studies have compared the interpretation of microscope slides with whole slide imaging (WSI) (also known as virtual microscopy or digital microscopy; Table 1) for primary diagnosis, consultation, or interpretation of frozen sections, (1-14) but many of those studies have been limited in scope, and few have measured the baseline intraobserver variability for glass microscope slide interpretation to which WSI intraobserver variability should be compared.
In the laboratory the "physical object" may be cells or tissues on a glass microscope slide.
The MX-96 Multispectral Array Microscope accomplishes this by scanning a glass microscope slide with 80 miniature microscope objectives simultaneously.
Under the new test, nurses will place a cell sample collected from the neck of the patient's womb into a fluid rather than smearing the collected material onto a microscope slide.
The ScanScope is an innovative microscope slide scanner that for the first time makes it practical to digitize entire slides, creating a virtual slide environment for automated microscopic inspection in pathology, cytology, hematology and related fields.
They bonded the other end to a glass plate, akin to a microscope slide.