The so-called solid ABC is a bone lesion that looks like the solid portion of an ABC throughout, that is, a solid to hemorrhagic fibrous lesion with scattered multinucleated giant cells
, variable osteoid production, and variable vascularity.
The histologic findings after review were ulceration and granulation tissue formation, granuloma, multinucleated giant cells
with many intracytoplasmic LeishmanDonovan bodies, numerous multinucleated giant cells
, severe lymphoplasma cells, infiltrating perineural tissue and muscles, pseudoepitheliomatous hyperplasia with keratin pearls, lymphoid aggregation in the submucosal area, lymphoid aggregation between skeletal muscles, and massive infiltration of macrophages loaded with Leishman-Donovan bodies in submucosal areas of oral (Figure 3), nasal, and respiratory epithelium.
Histologic analysis revealed a granulomatous dermatitis with a perineurovascular distribution of the infiltrate including multinucleated giant cells
and plasma cells.
The feature of multiple multinucleated giant cells
dispersed regularly within the spindle-cell stroma allows histologic distinction from many other giant cell-containing processes.
In some granulomas, Langhans-type or foreign-body-type multinucleated giant cells
Microbiology revealed no organisms, but histological investigation suggested an eosinophilic granuloma with dense eosinophilic infiltrates, histiocytes and scanty multinucleated giant cells
Biopsies of the antrum again showed noncaseating granuloma, and biopsies of the fundus showed chronic gastritis with multinucleated giant cells
Polymerase chain reaction amplification showed that parvovirus DNA was present in the nuclei of the multinucleated giant cells
and endothelial cells, Dr.
In addition to viral particles, HIV-infected cells can attach to and fuse with uninfected CD4+ cells, forming multinucleated giant cells
known as syncytia.
There is a highly vascular fibrous connective tissue stroma arranged in a storiform to whorled pattern, and it contains osteoclast-type multinucleated giant cells
Fine-needle aspiration of a left preauricular lymph node revealed multinucleated giant cells
and noncaseating granulomas consistent with granulomatous lymphangitis (Figure 2).
Microscopically the tissue composed of lobules of fibro-connective elements with abundant myxoid stroma, dystrophic calcification with scattered hemosiderin-laden macrophages, multinucleated giant cells
and occasional squamous cells.