B, The infiltrate is composed of lymphocytes, eosinophils, plasma cells, and prominent multinucleated giant cells
Presence of granulomatous reactions and multinucleated giant cells
in most of the patients with grades I, II, and microscopically negative lesions showed an inverse relation between the number of L-Bs and these chronic inflammatory cells.
Mononuclear infiltrate was greater with the formation of the multinucleated giant cells
, persistence of the interstitial edema and tissue necrosis.
Histologically, the tumor consists of numerous osteoclast-like multinucleated giant cells
, evenly distributed amongst round to spindled mononuclear cells .
Multinucleated giant cells
resembling osteoclasts were scattered throughout the tumor, and strands of hyaline and eosinophilic, highly cellular osteoid were arranged as irregular spicules or trabeculae separated by malignant cells (Fig 2C).
Inflammatory cytokine production by immunological and foreign body multinucleated giant cells
Giant cell tumor is a neoplasm composed of mononuclear, plump, round, oval or spindle--shaped stromal cells and osteoclast-like multinucleated giant cells
The H and E stained sections show presence of numerous multinucleated giant cells
in a back ground of cellular stroma composed of round to spindle shaped cells.
Giant cell tumors are distinctive neoplasms because they are characterized by a profusion of multinucleated giant cells
scattered throughout a stroma of mononuclear cells.
A physical examination revealed that the only positive finding was three lymph nodes situated close together in the submental zone, and a subsequent submental lymphadenectomy detected multiple foci of a non-caseating granulomatous reaction along with multinucleated giant cells
with some asteroid bodies, which were mostly consistent with sarcoidosis.
Histopathology demonstrated large numbers of osteoclast-type multinucleated giant cells
in a background of mononuclear stromal cells arranged in syncytial sheets.
The granulomas were composed of multinucleated giant cells
and "xanthogranulomatous cells" (diffusely in 4 cases, focally in the fifth).