Mutation

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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
It's a resounding confirmation of the regulation of mutagenesis by stress responses, which causes mutations specifically when cells are maladapted to their environment when mutations might allow the cell to adapt," said Rosenberg.
on directed mutagenesis in certain bacteria belittles the importance of natural selection in the evolutionary process particularly because no one expected that beneficial mutations could be induced from within the cell.
For optimum annealing conditions, we propose a length of 30-35 nucleotides for the mutagenesis reverse primer.
Many such investigations begin with random mutagenesis to identify genes of interest by a loss of function phenotype.
By deleting the calcium binding loop from subtilisin, the enzyme was destabilized, and the analysis of the structure and stability of the loop-deleted prototype followed by directed mutagenesis and selection for increased stability resulted in a subtilisin mutant with native-like proteolytic activity but 1000-times greater stability in strongly chelating conditions.
Most recently, he has begun to explore a new frontier of the field, involving the creation of novel enzyme catalysts via highly controlled chemical modifications of mutant enzymes constructed by site-directed mutagenesis.
Site directed mutagenesis of these four residues has indicated that His140 is the only histidine required for catalytic activity.
The reported research uses a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of direct current E-fields (DC/E) on a molecular genetic level.
Ixsys is currently using the Kauffman-Ballivet technology in conjunction with its other proprietary protein engineering technologies, such as Codon-Based Mutagenesis, to optimize the function of antibodies with therapeutic potential.
They point out that enzyme engineering through site-directed mutagenesis will provide additional avenues for refining the enzymes' specificites.
It currently offers next generation DNA sequencing, gene expression analysis, cloning, library construction, mutagenesis, genotyping and genetic stability testing.