Mutation

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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
Trovagene's proprietary KRAS assay enables physicians to determine mutational status, monitor treatment response, and use genomics to aid in predicting patient prognosis
KRAS mutational status ranks among one of the most important scientific advances in colorectal cancer and has the potential to redefine how these patients are currently treated.
As such, this semiautomated method, coupled with the low costs of analysis per sample, would be suitable for rapid, large-scale mutational screening of frequent and rare mutations.
There's growing interest in our molecular diagnostic tests by hematology-oncology specialists, particularly for the cell-free detection and monitoring of mutational status in patients with histiocytic diseases, as well as other hematologic malignancies that harbor the BRAF V600E mutation," said Mark Erlander, Ph.
In some cases, to test the effect of different variables on mutational analysis by SSCP, we selected samples known to harbor single nucleotide changes in the human insulin receptor (HIR) gene, in the adenomatous polyposis coli (APC) gene, and in the mismatch repair gene hMLH1 (11-13).
Prospective blinded study demonstrates ability to accurately determine mutational status and monitor response to BRAF inhibitor therapy from urinary cell-free DNA
BRAF V600E assay improves determination of mutational status and allows monitoring of treatment response
The full details of the structure are described in "Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors" in the June 12, 2007 issue of Proceedings of the National Acadamy of Sciences (PNAS).
Secondary objectives include correlating quantitative EGFR mutational load over time with tumor burden, and demonstrating detection of the resistant EGFR T790M mutation prior to clinical or radiographic progression in lung cancer patients treated with tyrosine kinase inhibitor therapy.
Today, genetic mutational tests (BRCA 1 and 2 genes) can detect genetic disposition of breast cancer risk, but aggressive screening, usually with breast MRI, is chosen more often than preventive mastectomy by patients who test BRCA-positive," he said.