A, qRT-PCR, and B, western blot analysis of the mRNA and protein levels of ALR, respectively, in U266 multiple myeloma cells
and healthy peripheral blood mononuclear cells (PBMCs).
Cell fusion: Sp2/0 myeloma cells
were grown in RPMI-1640 culture medium (added 10% FBS) for 4-5 d at 37degC in a 5% CO2 atmosphere.
In this study, pmaxGFP vectors were used to assess transfection success in RPMI 8226 myeloma cells
Previous studies have shown that growth hormone and somatomedin-C activate B lymphocyte and somatomedin-C receptors are found in multiple myeloma cells
To our knowledge, no detailed reports have so far been published regarding lipoplex and polyplex-mediated transfection of DNA into different myeloma cell
Histological parameters that have a definitive prognostic significance in multiple myeloma are the percentage of myeloma cells
in the marrow, pattern of infiltration, degree of plasma cell atypia, marrow fibrosis and mitotic index.
Inhibition of Aurora A has been shown to induce cell death in preclinical multiple myeloma cell
DMA(V) exerted differential antiproliferative and cytotoxic activity against leukemia and multiple myeloma cells
, with no significant effect on normal progenitor cells (Duzkale et al.
181 showed that uPAR expression depended on myeloma cell
maturation and that immature myeloma cells
had high expression levels.
The results, achieved in multiple myeloma cells
, offer a promising strategy for treating not only myeloma but also many other cancer types driven by the gene MYC, according to the study authors.
Elotuzumab, an investigational immunotherapy, is a humanized monoclonal antibody that enhances immune cell mediated killing of multiple myeloma cells
that have a surface protein called CS1.
Because BCMA has been shown to play a potential role in survival and growth of myeloma cells
, it is viewed as an attractive CAR T-cell therapeutic target.