Respiratory failure, due to akinesia, is a common cause of death, but renal failure, caused by myoglobinuria
secondary to muscle breakdown or heart failure, may also occur.
They can be associated with asymptomatic "hyper-CPK-emia"; transient myalgia and cramps with increased or normal CPK levels; persistent myalgia and cramps or weakness with increased or normal CPK levels; and rhabdomyolysis with myoglobinuria
, renal failure, and, when these are unrecognized and untreated, death, said Dr.
A diagnosis of rhabdomyolysis was made based on elevated serum creatine phosphokinase levels (7810 U/l) and myoglobinuria
Muscle ischemia and necrosis lead to oliguria, acidosis and myoglobinuria
with resulting azotemia, hyperkalemia and renal failure.
CPT2 is characterized by myalgia and myoglobinuria
as the body utilizes muscle as an alternative fuel source during activity, placing the patient at risk for rhabdomyolysis.
In this patient, rhabdomyolysis is evidenced by the increased plasma myoglobin level as well as the appearance of cola-colored urine which is characteristic of myoglobinuria
In general, FA oxidation disorders should always be included in the differential diagnosis of unexplained hypoglycaemia, metabolic acidosis, Reye's like syndrome, myopathy, recurrent myoglobinuria
, and cardiomyopathy (2).
Rhabdomyolysis: muscle symptoms associated with marked elevations in blood CK levels, significantly greater than 10 times the upper limit of normal and typically associated with myoglobinuria
The myotoxic action promotes widespread myalgy and myoglobinuria
(AzevedoMarques et al.
Thus, red cell counts may be falsely high if patients have myoglobinuria
was absent in this patient; however it is usually present only in patients with very high blood CPK levels, such as in the case of rhabdomyolysis, which, on the basis of the symptoms observed, could not be diagnosed in our patient.
Acute renal failure following kidney transplantation associated with myoglobinuria
in patients treated with rapamycin.