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| And subtle deformations of the optic nerve head -- changes truly characteristic of glaucoma -- prove difficult to spot and measure. Therefore, IOP as well as the perfusion of the optic nerve head should be monitored and managed appropriately. TNF-alpha is strongly upregulated in the optic nerve head of the glaucomatous eye, and TNF-alpha-induced apoptosis appears to be an important determinant of the progressive neurodegeneration characteristic of glaucoma. |
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