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When this enzyme is inhibited, acetylcholine remains in the neuromuscular junction and continues to activate the muscle cell.
Succinylcholine is resistant to the effects of acetylcholinesterase which allows a persistent and longer duration at the neuromuscular junction.
Myasthenia gravis (MG) is a treatable autoimmune disease in which the autoantibody is directed at the acetylcholine receptor (AChR) on the postsynaptic neuromuscular junction.
Adams PR (1987) Transmitter action at endplate membrane the vertebrate neuromuscular junction.
The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function.
It occurs when normal communication between the nerve and muscle is interrupted at the neuromuscular junction - the place where nerve cells connect with the muscles they control.
Researchers have long known that the so-called neuromuscular junction, a specialized structure similar to the synapses that link nerve cells in the brain, develops at a spot on the muscle determined by the nerve.
Pre-existing Neuromuscular Disorders Individuals with peripheral motor neuropathic diseases, amyotrophic lateral sclerosis, or neuromuscular junction disorders (eg, myasthenia gravis or Lambert-Eaton syndrome) should be monitored particularly closely when given botulinum toxin.
However, treatable causes such as paresis, menopause, and thyroiditis, as well as neuromuscular junction disorders such as myasthenia gravis, must be ruled out before attributing apparent atrophy to presbylaryngis.
The result of a defect at the neuromuscular junction, MG is characterized by fluctuating muscle weakness and fatigue.
These agents produce this effect at the neuromuscular junction by interfering with the action of the neurotransmitter acetylcholine (Ach).

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