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Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase.
Flow cytometric study of the expression of neutral endopeptidase (CD10/CALLA) on the surface of newborn granulocytes.
DPP IV Truncates BNP Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase.
Key words: green tea, neutral endopeptidase, angiotensin-converting enzyme, enzyme induction
Its longer duration of action is believed to relate to diminished affinity for the natriuretic peptide clearance receptor and increased resistance to the enzyme neutral endopeptidase, both pathways for clearance of endogenous natriuretic peptides.
9] Nonstandard abbreviafions: BNP, B-type natriuretic peptide; NT-proBNP, N-terminal pro-B-type natriuretic peptide; FDA, United States Food and Drug Administrafion; NP, natriuretic peptide; HAAA, human anti-animal antibody; ANP, atrial natriuretic peptide; NPR, natriuretic peptide receptor; and NEP, neutral endopeptidase.
The Food and Drug Administration's Cardiovascular and Renal Drugs Advisory Committee voted 5-1 against approving the drug, a selective inhibitor of the neutral endopeptidase enzyme and angiotensin-converting enzyme.