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From the results reported here, the accelerating effect of 2HT and IMZ salts can be justified, taking into consideration: (1) the presence of nitrogenous bases in both types of salts, in the imidazolinium ring and after thermal degradation occurring in vulcanization in 2HT, and (2) the increased mobility of sulfur anionic species.
Team member Yuichi Ando said among the four nitrogenous bases -- thymine (T), adenine (A), guanine and cytosine -- the researchers examined patient sequences of consecutive T and A bases called ''TATA boxes,'' which exist in genes activating enzymes that can prevent side effects of the drug.
The four nitrogenous bases of DNA are arranged along the sugar-phosphate backbone in a particular order (the DNA sequence), encoding all genetic instructions for an organism.