inhibitor

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Newer drugs are selecting for different types of resistance, especially in nucleoside reverse transcriptase inhibitors (NRTIs), so that there may not be large numbers of thymidine analog mutations (TAMs) developing in patients who have started therapy in recent years.
Surprisingly, support for this notion has come from testing the effect of removing single drugs from a failing regimen--in particular, nucleoside reverse transcriptase inhibitors (NRTIs).
Each dose of Trizivir is a fixed-dose combination of Ziagen (abacavir/ABC), Retrovir (zidovudine/AZT), and Epivir (lamivudine/3TC), three nucleoside reverse transcriptase inhibitors (NRTIs) already approved by FDA.
However, these 25 patients, all of whom were naive to non-nucleoside reverse transcriptase inhibitors (NNRTIs), were given efavirenz (Sustiva), a potent NNRTI, in addition to Kaletra and nucleoside reverse transcriptase inhibitors (NRTIs).
protease inhibitors, non- nucleoside reverse transcriptase inhibitors, nucleoside/nucleotide reverse transcriptase inhibitors) as well as the emerging classes," said John Lebbos, M.
The French have reported 8 cases of mitochondrial toxicity in uninfected infants with neonatal exposure to nucleoside reverse transcriptase inhibitors (NRTIs) who developed neurological and developmental abnormalities leading to 2 deaths.
The 3 components of Trizivir, all nucleoside reverse transcriptase inhibitors, have been previously approved for use in the United States.
Usually one PI is combined with 2 nucleoside reverse transcriptase inhibitors (NRTIs), the first class of approved antiretroviral drugs.
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