perforare

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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.
sup][12],[13] Compared to Tc1 cells, Tc17 cells exhibit strikingly suppressed cytotoxic activity by secreting low levels of the cytotoxic T lymphocytes markers: T-bet, IFN-a, perforin, and granzyme B.
London, Nov 1 (ANI): A new study has discovered how a protein 'assassin' called perforin punches holes in, and kills, rogue cells in our bodies.
CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages.
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells can induce apoptosis through multiple mechanisms, including the release of perforin and granzymes, cytokine release [IFN-[gamma], tumor necrosis factor (TNF)-[alpha], TNF-[alpha], interleukin (IL)-1], and triggering of Fas by FasL.
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
EFFECT OF TRIBUTYLTIN EXPOSURE ON THE EXPRESSION OF GRANZYME AND PERFORIN AND THE PHOSPHORYLATION STATE OF C-AMP RESPONSE ELEMENT BINDING PROTEIN IN HUMAN NATURAL KILLER CELLS.
IFN alpha-2b is known to stimulate both dendritic cells and CD4+ T-cells, which can ultimately produce various factors such as perforin that can destroy tumor cells.
Prostate tumor cells contain very low levels of two proteins, perforin and granzyme B, which can function together to kill cells.
Other mechanisms include secretion of perforin by cytotoxic T lymphocytes (CTLs) in lesional skin.