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Related to plasma cell disorders: multiple myeloma
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Although there are some potential limitations of the FLC assay (1), it has become an important tool for the diagnosis and management of plasma cell disorders.
The wide spectrum of presentations of patients with plasma cell disorders demands high diagnostic sensitivity in testing for M-proteins.
The subsequent sections highlight the role of miRNAs in commonly encountered hematopoietic malignancies like leukemias and plasma cell disorders (Table).
But the growing clinical acceptance of a serum free light chain assay has all but eliminated urine tests in identifying such plasma cell disorders as multiple myeloma (MM), smoldering myeloma, monoclonal gammopathy of undetermined significance (MGUS) and primary systemic amyloidosis (AL); and because the assay has proven to be more sensitive than IFE for detecting free or unbound immunoglobulin light chains when it is used in conjunction with SPEP, up to 99% of myelomas can be detected.
Their topics include a history of the kidney in plasma cell disorders, proximal tubular injury in myeloma, the mesangium as a target for glomerulopathic light and heavy chains, high-dose therapy, and current and emerging views and treatment of systemic immunoglobulin light-chain amyloidosis.
The diagnostic performance of serum FLC assay has been evaluated in patients with plasma cell disorders (4) including IgM paraproteins, including macroglobulinemia, IgM lymphoproliferative disorder, and lymphoma, but no detailed breakdown of data was available in this subgroup.