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Ristocetin-induced platelet agglutination is normal.
1% in general population) which is mostly due to the presence of EDTA-dependent antiplatelet antibodies that react optimally between 0 [degrees]C to 4 [degrees]C, recognise the cytoadhesive receptors gpUb/IIIa, stimulate the expression of activation antigen, trigger activation of trypsin kinase, platelet agglutination and clumping in vitro.
The vWF:RCo assay measures plasma vWF by testing the ability of vWF to induce platelet agglutination in the presence of the antibiotic ristocetin (3).