Symptoms of pneumonic plague
had developed in these 3 persons (Figure 2; Table 1).
emerged in new locations in the Oriental Province of DRC with outbreaks in 2005 and 2006.
In general, participants who perceived pneumonic plague
to be more severe, easier to catch, or more persistent in the environment were more likely to engage in precautionary behavior (Tables 1, 2).
The potential for application of the Proteosome technology to develop novel, safe and highly effective nasal vaccines against multiple bioterror agents, including Pneumonic Plague
, warrants serious consideration, especially given that other Proteosome-based vaccines have been safely administered to several hundred people in human clinical trials.
cholera, pneumonic plague
, yellow fever, viral hemorrhagic fevers) calls for a careful evaluation using the decision instrument to determine whether notification is indicated.
The incubation period for those patients was 1-4 days, which is consistent with that of pneumonic plague
is contagious through infectious respiratory secretions, potentially resulting in direct airway infection (primary pneumonic plague
) among close contacts (1,2).
Secondary pneumonic plague
may then occur if infection spreads to the lungs.
Taken together, these data suggest that the initial slope of an epidemic curve may be comparatively gradual during the first week, leading to slower recognition through syndromic surveillance than for other infections caused by bioterrorist agents with pulmonary manifestations, such as tularemia or pneumonic plague
For example, local-state-federal disagreements occurred in the management of the pneumonic plague
epidemic in Los Angeles in 1924, the last instance of person-to-person transmission of plague in the United States, as well as during the anthrax outbreak in 2001 (12,13).
may develop as the lungs become infected and it is especially dangerous because it may easily be spread by coughing.
It is the first case of pneumonic plague
seen in the state since 2004, said Jennifer House, a spokeswoman for the Colorado Department of Public Health and Environment.