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Michael Earl, co-CEO of Celtic Pharma Development Services, said: "The in-vitro data presented at the AAD demonstrate that TDT 067 potentiates the anti-fungal effects of terbinafine and the entry of the drug into dermatophyte hyphae, which we believe will provide a significant clinical benefit for the treatment of onychomycosis.
Alkaline refluxate can potentiate acidic damage, and it can cause its own damage to the esophagus and airway.
CEL-1000, when used as a single adjuvant (enhancer of a vaccine) or in combination with other adjuvants, potentiates Th1 (cellular) and innate (earliest stage) immune responses and protects animals from viral and parasitic challenge.
An array of positioned nucleosomes potentiates thyroid hormone receptor action in vivo.
The study demonstrated good in vivo anti-tumor activity against ovarian and lung cancer human xenograft tumor models by PX-866, and showed the agent significantly potentiates the antitumor activity of cancer therapeutics and other treatment modalities.
Interfering with methylation greatly potentiates the reactivation of HIV," said Kauder.
Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium.
It is a safe, commercially available drug (non-analgesic) that significantly potentiates the analgesic effects of opioids.
Tesmilifene is well ahead of other competing technologies, and if approved, it will not require oncologists to alter their existing treatment regimens because the compound potentiates existing chemotherapy drugs.
Acrylonitrile produces transient cochlear function loss and potentiates permanent noise-induced hearing loss.