With abdominal aortic constriction, the heart is challenged with an immediate pressure overload
and myocardial hypertrophy develops within days.
Further analysis indicated that PDGFR-beta in heart muscle cells contributes to the protective response to pressure overload
by triggering the growth of new blood vessels, providing new insight into the physiologic functions of PDGFR-beta.
In summary, RV failure is the result of inadequate contractility, volume or pressure overload
1993) Induction of cardiac insulin-like growth factor I gene expression in pressure overload
In contrast, much less known aspect of pressure overload
of RV is its impact on electrocardiographic (ECG) changes.
Taken together, these findings provide the first evidence that the effect of EGCG against cardiac fibrosis may be attributed to its inhibition on NF-KB activation and subsequent CTGF overexpression, suggesting the therapeutic potential of EGCG on the prevention of cardiac remodeling in patients with pressure overload
Right-sided heart failure due to acute pressure overload
is the usual cause of death from PE since the right ventricle is unable to generate and sustain a systolic pressure of 50 mmHg (3).
Measuring B-type natriuretic peptide, a cardiac neurohormone secreted by the ventricles as a specific response to volume expansion and pressure overload
, proved useful in identifying acute CHF in a pilot study, so Dr.
In our case, pulmonary dilatation developed due to the pressure overload
on pulmonary circulation caused by PHT.
Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload