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Pregnane X receptor activation induces FGF19- dependent tumor aggressiveness in humans and mice.
The facilitatory 5-HT(1B) receptor-mediated effect of the 5-HT(1B) receptor agonist on cocaine seeking may be related to the earlier reported enhancement of the rewarding properties of cocaine, while its inhibitory effect on cocaine-seeking behavior, unrelated to the 5-HT(1B) receptor activation, may result from a general reduction of motivation.
Blocking receptor activation that produces apoptosis.
2-4) In any case, it is the issue of adequate receptor activation that is important, not the level of the inactive 25-D precursor form.
Potentiation of oestrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
These assays include cell-based assays and high throughput compound assays to identify compounds that activate T1R1 or modulate T1R1 receptor activation by compound.
Other small molecules, called competitive antagonists, can bind to the site normally occupied by the neurotransmitter and prevent receptor activation.
Another approach, based on the development of new agonists with an improved receptor activation to receptor phosphorylation ratio, is also discussed.
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Excitotoxicity appears to be primarily dependent on NMDA and kainate receptor activation.
Receptor activation is triggered by both monomeric gp120 and whole HIV virus.
Using an assay where we could measure the ultimate effects of receptor activation on gene activity, we found that total receptor activity was reduced in the presence of the drug even at high concentrations of [alpha]-factor.

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