Mutation

(redirected from somatic mutation)
Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to somatic mutation: Somatic hypermutation

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
In addition to research involving heuristic approaches to mine somatic mutation data for relevant cancer genes, other researchers have developed increasingly sophisticated statistical approaches to identify significantly mutated genes in cancer.
Although the genomic landscape of serous endometrial carcinoma has recently been deciphered (1518 ), prior molecular studies of individual genes and pathways have established that serous endometrial carcinomas are characterized by a high frequency (up to 90% of cases) of somatic mutations in TP53 and/or p53 stabilization (48, 49).
The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory.
DNA microarrays have also been used for genotyping applications, including SNP typing, detection of genomic and somatic mutations, identification of microbes, and detection of allelic imbalances (6-11).
To date, no somatic mutations in BRCA1 have been reported in sporadic breast cancer, and only five somatic mutations have been identified in sporadic ovarian carcinomas (7, 8).
Determining this lower limit across many mutation types is important as a given sample may vary widely in tumor cellularity and somatic mutation profile.
2 Rating presence of somatic mutation in the gene Kalretikuliny (exon 9) performed in patients with suspected cancer myeloproliferative Ph (-) at the time of diagnosis.
Genentech identified more than 50,000 high-confidence somatic single nucleotide variations (SNVs), which yielded an estimated genome-wide somatic mutation rate of 17.
So far, we've found a pretty impressive somatic mutation rate of close to 50 percent in these tumors.
Most importantly, the human antibodies in the transgenic mice undergo class switching and somatic mutation from low affinity IgM class antibodies to high affinity human IgG class antibodies.
These antibodies then undergo class switching and somatic mutation in these transgenic mice to form high affinity fully human antibodies.
I present here a hypothesis that a strong antigen-induced proliferation is a mutational driver, which causes somatic mutations in lymphoid cells.