2 List of Figures Figure 1: Nociceptive Versus Neuropathic Pain 13 Figure 2: Etiology and Pathophysiology of NP 18 Figure 3: Pain Pathway - Somatosensory System
21 Figure 4: Pathophysiological Mechanisms of NP at Different Levels of the Nervous System 25 Figure 5: Pathophysiological Targets of NP Drugs 26 Figure 6: NeuSPIG Diagnostic Certainty Algorithm for NP 32 Figure 7: General Treatment Algorithm for NP 41 Figure 8: Competitive Assessment of Mid-to-Late Stage Pipeline Agents in NP, 2012-2022 66 To order this report: CNV-2197944 (Neuropathic Pain) - Forecast and Market Analysis to 2022 http://www.
Handbook of sensory physiology, Vol II: Somatosensory system
These sensory systems include the olfactory system, which detects odors, and the somatosensory system
, responsible for detecting irritants, chemicals that cause pain, tingling, burning, stinging, or prickling.
Neuropathic pain (NeP) is defined by the International Association for the Study of Pain (IASP) as pain arising as a direct consequence of a lesion or disease affecting the somatosensory system
(Loeser and Treede, 2008).
It covers the basic elements of the nervous system, including neurons and synapses, neurotransmitters and receptors, glial cells, and development, and the peripheral and central components of the somatosensory system
and their processing.
Because the vestibular system senses head motion, it is less sensitive to body sway than is the visual or the somatosensory system