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Major finding: Self-reported somnolence, poorer sleep quality, and sleep problems were associated with greater amyloid burden in areas of the brain known to be affected by Alzheimer's disease (P less than .
Common adverse reactions (occurring in [greater than or equal to]5% of subjects) included somnolence (45%), headache (26%), fatigue (16%), upper abdominal pain (11%), hypotension/decreased blood pressure (10%), vomiting (9%), dizziness (7%), nausea (7%), weight gain (7%), and irritability (6%).
The debate has penetrated even that cradle of somnolence, the Liberal Party caucus.
Ce dernier declenche alors une phase de somnolence, et le ver cesse de se mouvoir et entame une bonne sieste.
The most common adverse reactions (at least 5% for BRIVIACT and at least 2% more frequently than placebo) are somnolence and sedation, dizziness, fatigue, and nausea and vomiting symptoms.
The most common adverse reactions occurring in at least 5% of patients with BRIVIACT doses of at least 50 mg/day and greater than placebo were somnolence and sedation, dizziness, fatigue, and nausea and vomiting symptoms.
All the subjects reported excessive daytime somnolence.
But panelists expressed concerns about adverse effects associated with the drug in clinical trials, including high rates of somnolence and fatigue, a slightly higher rate of depression, the potential for drug and alcohol interactions, the lack of safety data on long-term use and during nursing and pregnancy--as well as the high withdrawal rate for adverse events in clinical trials.
Labeling will also note that sedation and somnolence were observed in trials.
concluded that treatment-emergent adverse events, including anorexia, nausea, somnolence, dizziness, and vomiting, were significantly more common among those taking atomoxetine.
Somnolence, slurred speech, amnestic dysphasia, and impaired fine motor control, but no meningism, focal signs, pyramidal tract, or sensation impairment, were observed.
Other areas of concern were cramping, pruritus, shivering, anxiety, and somnolence.