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congestion |
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The primary clinical manifestations of RF are recurrent high fever interrupted by afebrile periods, hepatomegaly, splenomegaly, and anemia. Patients may also present with lymphadenopathy, splenomegaly, hyperviscosity syndrome, cryoglobulinemia, peripheral neuropathy, cold agglutinin hemolysis, autoimmune thrombocytopenia, von Willebrand's disease and, in rare cases, amyloidosis. The splenomegaly and hematologic changes observed in these rats are suggestive of polycythemia. |
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