Hepatic stellate cell
line modulates lipogenic transcription factors.
A small study in HCV patients with 1200 IU alpha-tocopherol for 8 weeks resulted in blockage of the pathway for stellate cell
activation, preventing steatosis and fibrosis progression and an improvement in liver biopsy.
When called into action, stellate cells
produce fibrotic proteins in an attempt to heal an injury.
The role of matrix stiffness in hepatic stellate cell
activation and liver fibrosis.
It has been shown that endotoxin can directly induce hepatic stellate cell
activation through TL4.
The study has shown that liver X receptors (LXRs), master regulators of cholesterol, fat and inflammatory gene expression, also control the fibrosis-making cells of the liver, known as hepatic stellate cells
Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells
COL3A1 and a-SMA mRNA levels in activated rat HSCs and LX2 cells, an immortalized human hepatic stellate cell
In addition, TNFa also triggers NFkappaB activation, which induces stellate cell
activation and conversion into collagen secreting myofibroblasts.
Another pathway of stellate cell
activation by alcohol might be related to its common metabolism with compounds chemically related to vitamin A (i.
2]-Macroglobulin is a protease inhibitor whose concentrations increase with stellate cell
activation and liver fibrosis (21).
He was the first to isolate and characterize the hepatic stellate cell
, which is the key cell type responsible for scar production in liver.