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But all that changed after the stem cell mobilization protocol.
17-19) Intrinsic in the progress of IASCR following stem cell mobilization is a plausible proposal that homing of progenitor or ASC will occur in a reproducible manner.
Food and Drug Administration for an Investigational New Drug (IND) application for the stem cell mobilization indication.
However, six months after the injections, the researchers found no evidence that the stem cell mobilization factor provided any significant benefit.
The stem cell mobilization activity of burixafor will be highly desirable in increasing CD34+ cell yields in poor mobilizing donors.
NOX-A12 has shown promising activity in models of both hematological and solid tumors in addition to models of stem cell mobilization.
The company has also lodged an International patent application on ATL1102 based on preliminary data in mice and humans supporting its' potential application as a stem cell mobilization agent for use in combination with G-CSF to improve the level of stem cell release achieved with G-CSF alone.
Food & Drug Administration (FDA) confirming an Orphan Drug Designation of BL-8040 as a treatment for stem cell mobilization, in addition to the Orphan Drug Designation previously granted to BL-8040 as a treatment for Acute Myeloid Leukemia (AML).
Part 2 is an open-label study designed to assess BL-8040's stem cell mobilization capacity, as well as the yield of cells collected by leukapheresis.
Standard of care for patients with refractory or relapsing disease after initial therapy consists of a salvage therapy comprising a conventional chemotherapy regimen usually followed by stem cell mobilization and subsequent high-dose chemotherapy along with autologous stem cell transplantation.
According to the Company, the study demonstrates that the combination of these agents significantly increases hematopoietic stem cell mobilization in mice.
The CXCR4/SDF-1 axis has been shown to play a role in stem cell mobilization, vasculogenesis, tumor growth and metastasis.