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Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery. In six of the patients, Parkinson's symptoms temporarily improved and electrical activity in the subthalamic nucleus declined markedly and occurred at a more even pace than it had before the volunteers received the placebo. Since transient "positive" local signs are often encountered as a manifestation of neurologic events associated with a small acute hemorrhage, as illustrated by hemiballismus associated with hemorrhage in the subthalamic nucleus, this case provides substantial support for the concept that central tinnitus might indeed represent a pathologic activation of neural networks of nonspecific auditory perception. |
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