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Neuropathic pain syndromes resulting from lesions to the central nervous system include pain from spinal cord injury, multiple sclerosis, and stroke (eg, thalamic pain syndromes).
Cells depolarize and cellular depression spreads medially, which triggers thalamic pain centers as well as the nausea/vomiting center in the hypothalamus, and spreads down into the brain stem to hit the trigeminal nerve, causing the unilateral pain.
Among the topics are quality assurance using the known target point method, optic nerve sheath meningiomas, cavernous malformations with intractable seizures, and gamma knife pituitary radiosurgery for thalamic pain syndrome.