therapeutic

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However, the therapeutic plasma concentration was maintained within the dosing interval of 72 hours.
We performed a double-blind randomised controlled trial comparing these two practices to test the hypothesis that intraoperative intravenous administration of paracetamol would be more effective in achieving potentially therapeutic plasma concentrations in the early postoperative period than the same dose given orally preoperatively.
We wished to establish whether the IV preparation, the oral preparation or both achieve therapeutic plasma concentrations perioperatively and if so, for how long these are maintained and what maximum plasma concentrations are achieved.
Patients who took alternating doses of warfarin would have introduced random error into the measurement of the therapeutic plasma concentrations of S-warfarin, and data regarding the number of hours between the last warfarin dose and measurement of warfarin concentration were not available.

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