References in periodicals archive ?
Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery.
Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice.
In this study resulted that Occludin expression (Figure2) on intestinal tight junctions have function to protect tight junction integrity after treated by chemical stress such as LPS with dose of 2.
Green tea polyphenols alleviate early blood brain barrier damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signalling.
The 23 papers cover molecular properties of the tight junction; regulation of the tight junction and barrier function; and tight junctions in skin, lung, endothelia, and nervous tissues.
It has been demonstrated that supplementation of critically ill trauma patients with probiotic bacteria reduces the inflammatory cytokine response and attenuates the increase in intestinal permeability observed in such patients, [29] while animal work has shown that probiotics can prevent the inflammation-induced epithelial barrier defect associated with loss of tight junction proteins.
Cells have built in pathways that regulate tight junctions, in part by controlling the levels of both JAM and claudin.
ZO-1 and occluding phosphorylation are associated with stimulus-induced tight junction disassembly and paracellular permeability changes.
MLCK is thought to contribute to the damage of the GI epithelial barrier in other GI diseases such as inflammatory bowel disease [39] by selectively phosphorylating myosin II regulatory light chains, resulting in perijunctional actin-myosin contraction and redistribution of tight junction proteins, and leading to changes in the integrity of the mucosal barrier [40].
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.
Even out of a tight junction in the wet all you get is a blink from the yellow traction control light as it reigns in the power.