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Recording a narrative verdict, coroner Zafar Siddique said: "It is my conclusion that she died from renal failure because of toxicity of Tobramycin, as a result of the medical failings of the toxicology protocol not being followed.
This regimen and reduced dosing frequency was just as effective as tobramycin dosed qid for 5 days.
In these lethality-based studies, Zysolin(TM) consistently increased survival rate to 50% over a Tobramycin treatment group, wherein all untreated animals died within 24 hours after infection.
MARKHAM, ON, June 18 /PRNewswire-FirstCall/ -- AlphaRx (OTC BB:ALRX) is pleased to report a significant breakthrough in the development of Zysolin(TM), an inhaled Tobramycin nanoparticle formulation utilizing the company's proprietary drug delivery platform, and intended for the adjunctive treatment of Pseudomonas Aeruginosa Pneumonia in intubated and mechanically-ventilated patients (VAP).
In clinical trials, we have seen a reduction to one fourth of the inhalation time for PARI Tobramycin 100 compared to TOBI.
Fluidosomes-tobramycin combines the companys proprietary Fluidosomes technology with the well-established generic drug tobramycin.
Chiron Corporation (Nasdaq:CHIR) and Nektar Therapeutics (Nasdaq:NKTR) today announced the initiation of clinical testing in the Phase III program evaluating tobramycin inhalation powder (TIP), an investigational inhaled antibiotic.
Our lead product ARB-CF0223 - a liposomal formulation of tobramycin, delivered directly to the site of infection via standard nebulisers - produced very satisfying data from a phase I clinical trial; we initiated a clinical phase II trial and a subsequent capital increase was well received - and subscribed - by our existing private investors.
The randomized patients were treated for five days with either AzaSite or tobramycin ophthalmic solution.
Zysolin is a Tobramycin compound, encapsulated in AlphaRx's Nano Drug Delivery Platform, intended for the adjunctive treatment of Gram-negative pneumonia in intubated and mechanically-ventilated patients.