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The compound 4-amino pyridine produces powerful tonic convulsions of body and limbs.
In the electroconvulsive shock test, EHT 0202 significantly increased the current threshold for inducing tonic convulsions and in the psychomotor seizure (6 Hz) model in the mouse, EHT 0202 significantly decreased the forelimb seizure score.
The essential oil protected mice against tonic convulsions induced by maximal electroshock and especially by pentylenetetrazole.