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topical |
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In most cases, it's best to apply a topical agent, such as aloe vera gel or cream, to the affected skin and wait for it to heal. The initial medical anesthetic use of pure cocaine was in the 1880s as a topical agent in eye, nose, and throat surgeries because of its ability to provide anesthesia as well as to constrict blood vessels and limit bleeding. We have become aware that not only do systemic agents cause ototoxicity, but topical agents are also implicated (table 1). |
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