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Nutrients typically express such a high therapeutic index (ratio of some defined toxic dose to some defined therapeutic dose) that dual bioactivity is more accurately captured by at least two separate dose-response curves. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes. As in the case of PSP, arriving at a toxic dose of domoic acid in the 1987 episode was difficult because it was dependent largely on indirect measurements on recovered or uneaten products. |
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