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The PM can therefore help researchers assess the effects of environmental toxicants on cells.
These case studies will demonstrate prediction across structurally distinct liver toxicants and within complex organs, such as the kidney.
In the May 17 SCIENCE, the group reports finding that even though the new protein does not bind to TCDD, it must accompany this dioxin or the toxicant will never penetrate the cell nucleus.
Some of the NIEHS disaster response efforts are unique programs that will help identify the environmental hazards produced by Katrina as well as provide long-term insights into the link between environmental toxicants and health outcomes.
What the meeting established, Fowler says, is that for some toxicants, a porphyrinopathy may eventually prove more useful as an index of exposure--and perhaps even of developing toxicity--than any gauge that now exists.
Bredfeldt's observations strongly support the notion that arsemc metabolites may be functioning as the ultimate toxicants in arsenic-induced pathologies due to their heightened toxicity compared with inorganic arsenic.
As a consequence of transporter inhibition, cells and organisms can therefore become exposed to toxicants normally kept out of their cells.
Suggested topics and example research projects include, but are not limited to, first, integration of basic mechanism-driven and clinical patient-oriented research to gain new insights into the role of environmental factors in complex human diseases: 1) integration of patient phenotype data with high data content techniques such as transcriptomics, proteomics, and metabolomics to investigate the mechanisms by which exposures lead to disease; 2) comparison of animal/model organism and human responses to toxicants to identify biological alterations contributing to the disease etiology; 3) examination of the impact of current and/or prior environmental exposures on the progression, treatment, and survival of patients with existing disease.
These centers have also studied exposures to other environmental toxicants such as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and environmental tobacco smoke.
Humans and animals are always threatened by various toxicants naturally produced in different food products.
He introduces the principles of toxicology at the molecular, cellular, and organism levels, and the most important food-borne toxicants, such as endogenous plant toxicants; geochemical pollutants that plants absorb from the soil; environmental pollutants; mycotoxins; animal endogenous poisons; toxicants from aquatic animals; pesticide residues; veterinary drugs and feed additives; toxicants formed during processing, storage, and digestion; food additives; and vitamins.
Over 2,700 new citations identify previously unknown toxicants and provide all the technical details, while information on plant morphology and disease clinical signs brings together a range of ideas and approaches blending information sources for small and exotic animal practices.