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Similarly, gap junction uncouplers can at least partially prevent GVBD, even though follicle cells remain present near the non-maturing oocytes, following the apparent disruption of the follicle cell-oocyte junctions by the drugs.
These results suggest an overall shift in the mitochondrial redox state in the direction of oxidation (Chance, 1991) and parallel the effect observed with treatments of uncouplers (Blackstone and Buss, 1992, 1993; Blackstone, in press).
Effect of gap junction uncouplers on evoked luminescence
Field electrical stimulation induced facilitated flashes on a one-to-one basis with stimulation pulses, and this type of response was also largely and reversibly abolished in the presence of any of the three uncouplers (not shown).
Because the results from experiments with uncouplers and dye exchange suggested the involvement of gap-junction-like communication in the sea pansy, we next looked for gap junction proteins.
Thus the necessity of the integral luminescent tissue for the blocking effect of the uncouplers and the consistency of action of all three uncouplers on luminescent responses obtained by different means can best be explained by the involvement of some form of intercellular coupling in mediating the luminescent signal.
Nitrophenols are known protonophores and have been used in structural alert models to define uncouplers (Naven et al.
Hydroxyanthraquinones have been reported to be uncouplers of cellular respiration, and their potencies depend on the number and location of the hydroxyl groups (Betina and Kuzela 1987).
Under such conditions, uncouplers are able to increase oxygen consumption.
2012) Mitochondrial uncouplers inhibit hepatic stellate cell activation.
This is consistent with previous findings that showed that kava extracts act as inhibitors and uncouplers of the respiratory chain and inhibitors of [beta]-oxidation in isolated liver mitochondria (Lude et al.
carnea has suggested that morphological and life history differences paralleling those described above can be induced by perturbing the gastrovascular flow to peripheral stolons with treatments of uncouplers of oxidative phosphorylation and with treatments of increased feeding (Blackstone and Buss, 1992, 1993).