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Groups of ganglion cells and bundles of unmyelinated nerve fibers are present between the muscle layers.
Due to the constant pain caused by FM, small, unmyelinated nerve fibers are activated more frequently than the larger myelinated fibers (9).
Standard techniques for measuring nerve conduction velocities give only information on the largest and fastest conducting myelinated nerve fibers; therefore we were not able to detect any change in function of small, unmyelinated nerve fibers.