Histopathological examination revealed diffuse involvement of the spleen by cystically dilated vascular channels
most of which contained RBCs in their lumina.
Microscopy of the material revealed complex slit-like intercommunicating vascular channels
lined by atypical endothelial cells.
The patency of this vascular channel
enables blood to continue to flow between the aorta and the pulmonary artery.
Transungual surgical approach revealed shiny encapsulated tumour, which was excised en bloc and biopsy confirmed glomus tumour (Figure 3, 4) section showing tumour composed of variable sized vascular channels
surrounded by cells with abundant eosinophilic cytoplasm and monomorphic nuclei (H&E, 100X).
Histopathology showed a well-circumscribed tumor, lined by respiratory epithelium, composed of numerous vascular channels
Hemangiomas are classified histologically according to the predominant type of vascular channel
as capillary, cavernous, or mixed:
1) Vascular malformations are subclassified as either capillary, venous, lymphatic, or arterial according to the vascular channel
that predominates; some malformations involve a combination of vessels (e.
Prominent lymphatic or vascular channel
formation and dilation, as frequently noted in PT associated with emphysema, were not impressive in our cases.
The other theory was published in 1950 by Arey, who wrote that the canal is a remnant of a vascular channel
formed during osteogenesis.
Dilated vascular channel
in mid-dermal zone filled with RBCs.
The structures are frequently dysmorphic, meaning that each vascular channel
has variably thick and thin muscle walls.
Major Differential Diagnosis of Metastatic Angiosarcoma Metastatic Epithelioid Angiosarcoma Hemangioendothelioma Clinical features Young men Women Morphologic Lymphangitic or endovas- Bland neoplastic cells features cular growth pattern in chondroid or or neoplastic cells, myxoid stroma with vascular channel
formation CD31-factor VIII Positive Positive immunostains Kaposi Sarcoma Metaplastic Carcinoma Clinical features Acquired immunodeficien- Smokers, fifth to sixth cy syndrome decade Morphologic Malignant proliferation Pseudovascular channel features without anastomosing formation in a vascular spaces; pres- lymphangitic growth ence of intracyto- pattern plasmic and extracyto- plasmic eosinophilic bodies and extravasa- ted red cells CD31-factor VIII Positive Negative immunostains