wakefulness


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During normal periods of sleep, orexin system activity is suppressed, suggesting it is possible to purposefully counteract inappropriate wakefulness and facilitate the initiation and maintenance of sleep by interfering with orexin neurotransmission.
Their brain activity was also abnormal, more like normal wakefulness than sleep.
In individuals with insomnia disorder, it is possible that the orexin system which regulates sleep and wakefulness is not functioning normally.
Orexin neurons release two neuropeptides that interact with downstream receptors that promote wakefulness.
It was found that "high dream recallers" have twice as many time of wakefulness during sleep as "low dream recallers" and their brains are more reactive to auditory stimuli during sleep and wakefulness.
Coauthor Robert Greene, professor of psychiatry and a physician at the Dallas VA Medical Center, indicates the study is unique in showing that the need for sleep (called sleep homeostasis) can be separated from wakefulness both behaviorally and biochemically, meaning the two processes now can be studied individually.
The reason: "It's likely that people at the height of their wakefulness perform better athletically," says Winter.
Because breath sounds are directly related to pharyngeal pressure, "this method is sensitive to the seventy of [OSA] even during wakefulness.
1A] receptor agonist 8-OH-DPAT and antagonist p-MPPI on sleep and wakefulness responses elicited by spinosin in pentobarbital-treated rats.
Further pointing to the role of adenosine A1 receptors in sleep, studies demonstrate that chemically blocking (antagonizing) adenosine Al receptors in mammals results in increased wakefulness.
Levels of a protein that forms the hallmark plaques of Alzheimer's disease rise in the brains of mice and in the spinal fluid of people during wakefulness and fall during sleep, researchers report online September 24 in Science.
It is still unclear whether the mutation affects sleep quantity alone or also wakefulness.