(redirected from Affinity maturation)
Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.


The relationship that a person has to the blood relatives of a spouse by virtue of the marriage.

The doctrine of affinity developed from a Maxim of Canon Law that a Husband and Wife were made one by their marriage. There are three types of affinity. Direct affinity exists between the husband and his wife's relations by blood, or between the wife and the husband's relations by blood. Secondary affinity is between a spouse and the other spouse's relatives by marriage. Collateral affinity exists between a spouse and the relatives of the other spouse's relatives. The determination of affinity is important in various legal matters, such as deciding whether to prosecute a person for Incest or whether to disqualify a juror for bias.

West's Encyclopedia of American Law, edition 2. Copyright 2008 The Gale Group, Inc. All rights reserved.


the relationship or connection between one spouse and the blood relatives of the other. See CONSANGUINITY.
Collins Dictionary of Law © W.J. Stewart, 2006

AFFINITY. A connexion formed by marriage, which places the husband in the same degree of nominal propinquity to the relations of the wife, as that in which she herself stands towards them, and gives to the wife the same reciprocal connexion with the relations of the husband. It is used in contradistinction to consanguinity. (q.v.) It is no real kindred.
     2. Affinity or alliance is very different from kindred. Kindred are relations. by blood; affinity is the tie which exists between one of the spouses with the kindred of the other; thus, the relations, of my wife, her brothers, her sisters, her uncles, are allied to me by affinity, and my brothers, sisters, &c., are allied in the same way to my wife. But my brother and the sister of my wife are not allied by the ties of affinity: This will appear by the following paradigms

     My wife's father ---|
     | |
     | |
     -----------------| |
     | | |-- are all allied to me. Ego ----- My Wife My wife's sister ---|
     | |
     My wife's niece ---|
     My wife's father ---|
     My Father | | |My brother
     | | | |and my wife's
     | | | |sister are
    |---------------| |----------| |not allied
    | | | | |to each other My brother Ego ---- My wife, My wife's sister |

     3. A person cannot, by legal succession, receive an inheritance from a relation by affinity; neither does it extend to the nearest relations of husband and wife, so as to create a mutual relation between them. The degrees of affinity are computed in the same way as those of consanguinity. See Pothier, Traite du Mariage, part 3, ch. 3, art. 2, and see 5 M. R. 296; Inst. 1, 10, 6; Dig. 38, 10, 4, 3; 1 Phillim. R. 210; S. C. 1 Eng. Eccl. R. 72; article Marriage.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
References in periodicals archive ?
The specific affinity maturation in Anisakis-associated allergic disease has not been studied so far, but our results could lead to a testable hypothesis, where clinically different CU+ and GAA after parasitism could be motivated by distinct class switching of specific antibodies.
(1999), "Receptor editing during affinity maturation", Immunol Today, 20 (4): 196-196.
Among the topics are filamentous bacteriophage structure and biology, leveraging synthetic phage-antibody libraries for panning on the mammalian cell surface, high-throughput and high-content screening using peptides, antibody humanization and affinity maturation using phage display, and native antibody libraries from natural repertoires.
Their activity may rely either on molecular excess or on affinity maturation during vaccination (28).
Second, yeast display offers a faster and less labor-intensive path for optimizing a molecule of interest through affinity maturation."
19 February 2014 - Canadian Innovative Targeting Solutions Inc, a developer of protein engineering technologies, said Tuesday that its HuTARG affinity maturation technology had successfully produced antibodies with pM affinities.
AxioMx noted that it had received orders for more than USD 750,000 for custom services including antigen design, antibody discovery and development, and affinity maturation of existing antibodies during the last nine months.