antagonist

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Related to Aldosterone antagonist: potassium sparing diuretics
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Table-3: Different aldosterone antagonists prescribed to patients.
Currently, two aldosterone antagonists are available commercially.
The important caveat regarding the aldosterone antagonists is that they should be used only in patients with an estimated glomerular filtration rate greater than 30 mL/min per 1.73 [m.sup.2] and a serum potassium level below 5.0 mEq/dL.
Angiotensin converting enzyme inhibitors used in combination with aldosterone antagonists decrease the risk of progressive cardiac failure and sudden cardiac death (24).
Past animal experiments reported that chronic exposure to elevated aldosterone causes myocardial fibrosis in rats that are maintained on a high-salt diet [8] and that these changes are prevented by either administration of aldosterone antagonists or adrenalectomy [9].
Yet the aldosterone antagonist actually showed a significant positive result for the composite endpoint in North and South American participants.
Although aldosterone antagonists are appropriate for use in patients with heart failure (A), we recommend they are taken under the care of a cardiologist to minimize complications and to insure that a complete heart failure plan is in place (C).
This study wasn't designed to determine why the results contradicted the "impressive benefits of aldosterone antagonist therapy" reported in "pivotal" effica cy trials as well as in a systematic review of randomized clinical trials of the therapy.
Boxer noted that serum aldosterone level in patients with heart failure predicts mortality Aldosterone blockade with an aldosterone antagonist has been shown to improve clinical outcomes in heart failure patients with a depressed left ventricular ejection fraction in RALES, the Randomized Aldactone Evaluation Study (N.
This study wasn't designed to determine why the results contradicted the "impressive benefits of aldosterone antagonist therapy" reported in "pivotal" efficacy trials as well as in a systematic review of randomized clinical trials of the therapy.
The best multidrug combinations for isolated systolic hypertension include diuretics; ACE inhibitors or angiotensin receptor blockers; dihydropyridine calcium channel blockers; and an aldosterone antagonist, he said.
PARIS -- The aldosterone antagonist eplerenone cut cardiovascular events and the need for hospitalization significantly across all risk levels in patients with mild heart failure, according to a subanalysis of EMPHASIS-HF trial data.