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In the alternative complement pathway, C3b reacts with the proteins factor B, adipsin, and properdin to compose C3 convertase.
Activation of the alternative complement pathway by EBV and the viral envelope glycoprotein, gp350.
Complement factor B mutations lead to continuous activation of the alternative complement pathway.
Similarly, oral administration of [beta]-glucan did not induce changes in alternative complement pathway in previous studies (Ogier de Baulny et al.
Thanks to its mechanism of action and high target specificity, TNT009 selectively inhibits disease processes in the Classical Complement pathway cascade and keeps the vital immune surveillance provided by the Alternative Complement Pathway and Lectin Complement Pathway.

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