The scholars that highlight
Ames test limitations point to the fact that it is utilizing bacteria that is very different from human cell and therefore advocate for models using human or mammalian cells.
All chemicals and raw materials for the
Ames test were purchased from Molecular Technology Inc.
In contrast, the samples collected at points P3 and P4 showed a positive response to the
Ames test, and at point P4 a cytotoxic response was found at concentrations greater than 1200 [micro]g/plate.
Using the
Ames test, a compound is considered mutagenic if it reaches at least two-times the number of colonies of the spontaneous reversion.
Comparison of the Ames II and traditional
Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity.
3) This is not, however, at the expense of its sensitivity, which is higher than that of the current gold standard
Ames test.
The same prepared extract of fresh feces and urine used for HPLC analysis was also assessed for mutagenicity by the
Ames Test using Salmonella typhimurium TA 98 (Ames et al.
In the
Ames test, not all substances that cause mutations in bacteria are found to cause cancer in animals or man.
The safety concern arises from the fact that ginger has been found to be teratogenic on the
Ames test.
The safety concern arises from the fact that ginger is found to be teratogenic on the
Ames test.
The
Ames test has become the standard by which many substances are measured for mutagenacity and carcinogenicity.
Commonly found in feces, 7-OHIQ was identified during the 1980s as a direct-acting mutagen in the
Ames test, a bacterial assay used to screen for potential carciongens.
