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Preserved endocrine function in a pancreas transplant recipient with pancreatic panniculitis and antibody-mediated rejection.
C4d-positive interacinar capillaries correlates with donor-specific antibody-mediated rejection in pancreas allografts.
Acute cellular and antibody-mediated rejection of the pancreas allograft: incidence, risk factors and outcomes.
Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft.
Eculizumab treatment of acute antibody-mediated rejection in renal transplantation: case reports," Transplantation Proceedings, vol.
Case report: eculizumab rescue of severe accelerated antibody-mediated rejection after ABO-incompatible kidney transplant," Transplantation Proceedings, vol.
Eculizumab for salvage treatment of refractory antibody-mediated rejection in kidney transplant patients: case reports," Transplantation Proceedings, vol.
Pascual, "Eculizumab to treat antibody-mediated rejection in a 7-year-old kidney transplant recipient," Pediatrics, vol.
In all cases, the acute antibody-mediated rejection was very responsive to additional plasmapheresis/CMV-HG therapy.
The basis of this protocol is that the antibodies that would lead to hyperacute rejection or acute antibody-mediated rejection must be removed from the body, and the immune system must be modulated to reduce the production of the antibody in the future or dampen the immune response to the foreign antigen.
The presence of C4d, a complement degradation product, usually confirms the diagnosis of acute antibody-mediated rejection (Pascual et al.
However, the John Hopkins group (23) has recently challenged the previous hypothesis by demonstrating that low levels of DSA were associated with subclinical antibody-mediated rejection and/or chronic allograft nephropathy 1 year after transplantation.

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