Because influenza viruses are constantly undergoing antigenic drift
, the composition of vaccines must be updated each year, and annual vaccination is recommended.
refers to successive small point mutations that occur with successive replication.
At present that is not the case, but influenza viruses are notorious for their ability to mutate via a process called antigenic drift
produces new virus strains that may not be recognized by antibodies to earlier influenza strains.
Experience in the production of influenza vaccines is also considerable, particularly because vaccine composition changes each year to match the antigenic drift
in circulating virus.
Both antigenic shift, involving minor antigenic changes in the HA and NA glycoproteins, and antigenic drift
, involving major changes, have been described.
This is because, in spite of mutations and antigenic drift
, all influenza viruses bind to the same cell surface receptor called sialic acid, and the Company has developed small chemical ligands that mimic this receptor, to attack the influenza viruses.
Market Driver - Increased Awareness on H1N1 Influenza - For a full, detailed list, view our report Market Challenge - Antigenic Drift
of H1N1v Virus - For a full, detailed list, view our report Market Trend - Emergence of Quadrivalent Vaccines - For a full, detailed list, view our report Key Questions Answered in this Report - What will the market size be in 2018 and what will the growth rate be?
Similar to other viruses in the antigenic cluster, H3N2-[beta] A/swine/Texas/ A01104013/2012(H3N2) had a R189K mutation at the antibody-binding site of the hemagglutinin protein, which caused a recent antigenic drift
in subtype H3N2 IAVs (5,12).
SEEK's vaccine is designed to protect against both type A and B viruses, as well as antigenic drift
within each virus type.
Our chances of having a perfect vaccine match during an outbreak may be low due to antigenic drift
, but if we have a vaccine that offers some protection in the face of an epidemic like the one in 1918-1919, significant amounts of morbidity and mortality could be averted.
Having such a process in place gives some assurance that researchers would be able to respond quickly to any antigenic drift
the H5 virus might experience, Dr.