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Focusing on the development of the fifth and sixth aortic arches in the zebrafish, Dr.
Aortic arches are dissected from day 12-14 chick embryos and cut into rings similar to those of the rat aorta.
Papaioannou of Harvard Medical School found that embryonic mice without Tbx1 have malformations of the aortic arches, which become the major arteries leaving the heart.