(9.) Chhieng DC, Cangiarella JF: Atypical glandular cells
. Clin Lab Med 2003, 23(3):633-57.
Management of atypical glandular cells
and adenocarcinoma in situ.
HPV-16 20 (32) 62 HPV-18 3 (50) 6 Non-16/18 hrHPV 25 (23) 107 Mixed hrHPV 8 (20) 40 Abbreviations: HGCL, high-grade cervical lesions, encompassing atypical squamous cell, cannot rule out high-grade squamous intraepithelial lesion, atypical glandular cells
, and high-grade squamous intraepithelial lesion;hr, high-risk; LGCL, lower-grade cervical lesions, encompassing low-grade squamous intraepithelial lesion and atypical squamous cells of undetermined significance; NILM, negative for intraepithelial lesions or malignancies.
Chhieng et al  conducted a study on the clinical significance of Atypical glandular cells
in postmenopausal women.
The evaluation of the patient with atypical glandular cells
in her Pap smear demands caution and the experience of experts.
Clinical utility of adjunctive high-risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells
. Arch Pathol Lab Med.
Ten (9.8%) cases showed atypical squamous cells of undetermined significance (ASCUS) and four (3.9%) cases had atypical glandular cells
of undetermined significance (AGUS).
(%) P Value (Multiple Responses (n = 531) (n = 560) Allowed) ASC-US reflex 476 (89.6) 503 (89.8) .92 Nonreflex test 404 (76.1) 332 (59.3) < .001 requested anytime Cotest for women aged 320 (60.3) 137 (24.5) < .001 30 y and older ASC-H reflex 227 (42.7) 269 (48.0) .08 LSIL reflex 158 (29.8) 156 (27.9) .49 AGC reflex 145 (27.3) 111 (19.8) .003 HSIL reflex 123 (23.2) 121 (21.6) .54 Abbreviations: AGC, atypical glandular cells
; ASC-H, atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade intraepithelial lesion.
(%) 5707 (2.7) 5820 (2.7) Abbreviations: ADC, adenocarcinoma; AGC, atypical glandular cells
; AIS, adenocarcinoma in situ; ASC-H, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; SCC, squamous cell carcinoma.
(65) Not infrequently, these patients have a previous cervical smear with atypical glandular cells
that may be interpreted as atypical glandular cells
or suspicious for AIS.